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Raman optical activity of an achiral element in a chiral environment

Smith, A.M. and Collins, R.F. and Ulijn, R.V. and Blanch, E. (2009) Raman optical activity of an achiral element in a chiral environment. Journal of Raman Spectroscopy, 40 (9). pp. 1093-1095. ISSN 0377-0486

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Raman optical activity (ROA) is a relatively new technique used to determine the structure of chiral molecules and is proving useful in the study of biological molecules such as proteins and DNA/RNA. Here, for the first time, we demonstrate the applicability of ROA as a technique to study achiral groups in chiral environments, detecting the induced chirality of N-(fluorenyl-9-methoxycarbonyl) (Fmoc) in a chiral self-assembled structure of Fmoc-dipeptides. This technique is therefore of interest to those studying self-assembled systems that adopt a chiral structure.