Mechanisms and dynamics of protein clustering on a solid surface
Mulheran, P.A. and Pellenc, D. and Bennett, R.A. and Green, R.J. and Sperrin, M. (2008) Mechanisms and dynamics of protein clustering on a solid surface. Physical Review Letters, 100 (6). 068102. ISSN 1079-7114 (https://doi.org/10.1103/PhysRevLett.100.068102)
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A methodology for discovering the mechanisms and dynamics of protein clustering on solid surfaces is presented. In situ atomic force microscopy images are quantitatively compared to Monte Carlo simulations using cluster statistics to differentiate various models.We study lysozyme adsorption on mica as a model system and find that all surface-supported clusters are mobile, not just the monomers, with diffusion constant inversely related to cluster size. The surface monomer diffusion constant is measured to be D-1 similar to 9x10(-16)cm(2) s(-1), such a low value being difficult to measure using other techniques.
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Item type: Article ID code: 15110 Dates: DateEvent12 February 2008PublishedSubjects: Science > Chemistry > Physical and theoretical chemistry
Science > Physics > Solid state physics. NanoscienceDepartment: Faculty of Engineering > Chemical and Process Engineering Depositing user: Dr Paul A Mulheran Date deposited: 03 Feb 2010 16:37 Last modified: 08 Apr 2024 17:02 URI: https://strathprints.strath.ac.uk/id/eprint/15110