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Open Access research which pushes advances in bionanotechnology

Strathprints makes available scholarly Open Access content by researchers in the Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS) , based within the Faculty of Science.

SIPBS is a major research centre in Scotland focusing on 'new medicines', 'better medicines' and 'better use of medicines'. This includes the exploration of nanoparticles and nanomedicines within the wider research agenda of bionanotechnology, in which the tools of nanotechnology are applied to solve biological problems. At SIPBS multidisciplinary approaches are also pursued to improve bioscience understanding of novel therapeutic targets with the aim of developing therapeutic interventions and the investigation, development and manufacture of drug substances and products.

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Pulsed light technology for microbial inactivation

Endarko, A. and MacLean, M. and Timoshkin, I. and MacGregor, S.J. and Anderson, J.G. (2009) Pulsed light technology for microbial inactivation. In: The 44th International Universities' Power Engineering Conference, 2009-09-01 - 2009-09-04.

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Abstract

Pulsed ultraviolet-rich (PUV) light is a novel nonthermal high-peak power technology, which can achieve rapid inactivation of pathogenic and spoilage microorganisms. The aim of this study was to determine the effect of PUV-light for the inactivation of the bacterial species Staphylococcus epidermidis and the yeast species Saccharomyces cerevisiae whilst in liquid suspension. Results demonstrate that PUV-light exposure is highly microbicidal, with a 7-logl o reduction of S. epidermidis being achieved after application of less than 10 pulses. S. cerevisiae was also inactivated, with 5-logl o and 7-logl o reductions being achieved after exposure to 10 and 75 pulses, respectively. This study also demonstrates that agitation of the sample during PUV exposure significantly enhances the inactivation rate of densely populated microbial suspensions.