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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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The partition of temporal gene expression sequence using discrete wavelet transform for modelling

Yu, L. and Marshall, S. (2009) The partition of temporal gene expression sequence using discrete wavelet transform for modelling. In: IEEE Workshop on Genomic Signal Processing, 1900-01-01.

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Abstract

Switch-like phenomena within biological systems complicate the inference of gene regulatory networks. In this case, the difficulty comes from the fact that the model cannot be inferred from the mixed unknown contexts directly. It is necessary to identify the dasiapurepsila contexts from the data and given a dasiapurepsila context, subsequently infer a model. In this paper, a wavelet-based approach is addressed for the efficient partitioning of data into different biological contexts. The wavelet transform is a well known tool from the signal processing domain. This approach is able to identify the switches in the various conditions, with much lower computational cost than existing techniques. In order to demonstrate the proposed algorithm, experiments on the basis of simulated sequences and a synthetic sequence derived from real gene networks have been performed.