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Literary linguistics: Open Access research in English language

Strathprints makes available Open Access scholarly outputs by English Studies at Strathclyde. Particular research specialisms include literary linguistics, the study of literary texts using techniques drawn from linguistics and cognitive science.

The team also demonstrates research expertise in Renaissance studies, researching Renaissance literature, the history of ideas and language and cultural history. English hosts the Centre for Literature, Culture & Place which explores literature and its relationships with geography, space, landscape, travel, architecture, and the environment.

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Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds

Henriquez, Fiona L. and Ingram, Paul R. and Muench, Stephen P. and Rice, David W. and Roberts, Craig W. (2008) Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds. Antimicrobial Agents and Chemotherapy, 52 (3). pp. 1133-1135. ISSN 0066-4804

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Abstract

Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers.