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Strathprints makes available scholarly Open Access content by the Fraser of Allander Institute (FAI), a leading independent economic research unit focused on the Scottish economy and based within the Department of Economics. The FAI focuses on research exploring economics and its role within sustainable growth policy, fiscal analysis, energy and climate change, labour market trends, inclusive growth and wellbeing.

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Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds

Henriquez, Fiona L. and Ingram, Paul R. and Muench, Stephen P. and Rice, David W. and Roberts, Craig W. (2008) Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds. Antimicrobial Agents and Chemotherapy, 52 (3). pp. 1133-1135. ISSN 0066-4804

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Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers.