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Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Fairhead, Michael and Johnson, Kenneth A. and Kowatz, James H. and McMahon, Stephen A. and Carter, Lester G. and Oke, Muse and Liu, Huanting and Naismith, James H. and van der Walle, Christopher F. (2008) Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras. Chemical Communications (London), 2008 (15). pp. 1765-1767. ISSN 0009-241X

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Abstract

Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5A ˚ crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.