Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Fairhead, Michael and Johnson, Kenneth A. and Kowatz, James H. and McMahon, Stephen A. and Carter, Lester G. and Oke, Muse and Liu, Huanting and Naismith, James H. and van der Walle, Christopher F. (2008) Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras. Chemical Communications (London), 2008 (15). pp. 1765-1767. ISSN 0009-241X (https://doi.org/10.1039/b718264c)

Abstract

Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5A ˚ crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.

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• Item metadata

  Item type:	Article
  ID code:	12974
  Dates:	Date Event 21 April 2008 Published
  Subjects:	Medicine > Therapeutics. Pharmacology Medicine > Pharmacy and materia medica Science > Microbiology
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Ms Ann Barker-Myles
  Date deposited:	28 Aug 2009 09:42
  Last modified:	11 Nov 2024 09:03
  URI:	https://strathprints.strath.ac.uk/id/eprint/12974