Brown, R. and Smith, W.E. and Graham, D. (2001) Synthesis of a benzotriazole phosphoramidite for attachment of oligonucleotides to metal surfaces. Tetrahedron Letters, 42 (11). pp. 2197-2200. ISSN 0040-4039
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1016/S0040-4039(01)00108-3
Abstract
A method for the addition of a benzotriazole moiety to the 5'-terminus of an oligonucleotide via phosphoramidite chemistry has been developed. Use of a monomethoxytrityl protecting group on the benzotriazole allowed fast on-column detritylation purification by reverse-phase HPLC. Surface enhanced Raman scattering (SERS) of the modified oligonucleotides was obtained from silver colloid.
| Item type: | Article |
|---|---|
| ID code: | 967 |
| Keywords: | HPLC, nucleic acids, phosphoramidites, solid-phase synthesis, SERS, Chemistry |
| Subjects: | Science > Chemistry |
| Department: | Faculty of Science > Pure and Applied Chemistry Unknown Department |
| Related URLs: | |
| Depositing user: | Mr Derek Boyle |
| Date Deposited: | 05 May 2006 |
| Last modified: | 12 Mar 2012 10:36 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/967 |
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