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World class computing and information science research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.

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Contractile behaviour of 3T3 mouse fibroblasts in artificial skin substitutes: effect of different cell-seeding methods

Ho, G. and Grant, M.H. and Barbenel, J.C. (2002) Contractile behaviour of 3T3 mouse fibroblasts in artificial skin substitutes: effect of different cell-seeding methods. European Cells and Materials, 4 (2). pp. 55-56. ISSN 1473-2262

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Abstract

With the rapid development of tissue engineering and gene therapy, collagen-based biomaterials are frequently used as cell transplant devices; an example is bio-artificial skin substitutes [1-3]. In this study, we determined the effects of two different cell-seeding methods, monolayer and suspension seeding, on the rate of contraction of free-floating collagen and collagenglycosaminoglycan (GAG) gel matrices in vitro. 3T3 mouse fibroblasts were cultured in/on the matrices for up to 7 days.