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Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways

Dick, Lindsay and Dooley, Neil and Elliott, Moira A and Ford, Steven J and Gordon, Malcolm R and Halbert, Gavin W and Kerr, William J (2011) Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways. Journal of Pharmaceutical and Biomedical Analysis, 56 (3). pp. 633-636.

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Abstract

Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.

Item type: Article
ID code: 34327
Notes: Copyright © 2011 Elsevier B.V. All rights reserved.
Keywords: BPA, degradation, impurities, HPLC, BNCT, Pharmacy and materia medica, Drug Discovery, Pharmaceutical Science, Spectroscopy, Analytical Chemistry, Clinical Biochemistry
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Pure and Applied Chemistry
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
Related URLs:
Depositing user: Pure Administrator
Date Deposited: 27 Jan 2012 13:19
Last modified: 27 Mar 2014 09:41
URI: http://strathprints.strath.ac.uk/id/eprint/34327

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