Dick, Lindsay and Dooley, Neil and Elliott, Moira A and Ford, Steven J and Gordon, Malcolm R and Halbert, Gavin W and Kerr, William J (2011) Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways. Journal of Pharmaceutical and Biomedical Analysis, 56 (3). pp. 633-636.
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1016/j.jpba.2011.06.025
Abstract
Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.
| Item type: | Article |
|---|---|
| ID code: | 34327 |
| Notes: | Copyright © 2011 Elsevier B.V. All rights reserved. |
| Keywords: | BPA, degradation, impurities, HPLC, BNCT, Pharmacy and materia medica |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Science > Pure and Applied Chemistry |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 27 Jan 2012 13:19 |
| Last modified: | 10 Apr 2013 10:26 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/34327 |
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