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Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Selective protection of 5-aminobenzotriazole for controlled reaction at the primary amine

McKeown, D. and McHugh, C.J. and McCabe, A. and Smith, W.E. and Graham, D. (2002) Selective protection of 5-aminobenzotriazole for controlled reaction at the primary amine. Heterocycles, 57 (7). pp. 1227-1230. ISSN 0385-5414

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Abstract

The selective protection of the triazole function of 5-aminobenzotriazole is reported. Two different protecting groups were used to prevent side reactions through the triazole amine acting as a leaving group when 5-aminobenzotriazole was used as a nucleophile. This allowed the addition of aminobenzotriazole to two target molecules to impart metal complexing properties to the new species.