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Internal labeling of oligonucleotide probes by Diels-Alder cycloaddition

Graham, D. and Grondin, A. and McHugh, C. and Fruk, L. and Smith, W.E. (2002) Internal labeling of oligonucleotide probes by Diels-Alder cycloaddition. Tetrahedron Letters, 43 (27). pp. 4785-4788. ISSN 0040-4039

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A new method of adding fluorescent labels to the middle of oligonucleotides is reported. Diets-Alder cycloaddition was used to add five fluorescent maleimides to an oligonucleotide containing a 2'-deoxyuridine modified at the 5-position with a spaced furan. This is a new approach to internal oligonucleotide chemistry that opens Lip a large range of possibilities for further conjugation.