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Reduced glutathione levels and expression of the enzymes of glutathione synthesis in cryopreserved hepatocyte monolayer cultures

Stevenson, D. and Morgan, C. and McLellan, L.A. and Grant, M.H. (2007) Reduced glutathione levels and expression of the enzymes of glutathione synthesis in cryopreserved hepatocyte monolayer cultures. Toxicology, 231 (2-3). pp. 100-101. ISSN 0300-483X

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Abstract

Cryopreservation of hepatocytes as monolayers circumvents the problems of low post-thaw recovery and attachment in culture obtained with hepatocytes frozen in suspension. We have shown that cytochrome P450 dependent generation of reactive metabolites takes place readily in these cells (Stevenson et al., 2004), and in the present study the reduced glutathione (GSH) levels and the expression of the catalytic subunit of glutamate cysteine ligase (GCL) and of glutathione synthetase (GSS) have been investigated.

Item type: Article
ID code: 9905
Notes: See also journal article: http://strathprints.strath.ac.uk/28452/
Keywords: cryopreserved hepatocyte monolayers, reduced glutathione, glutathione synthesis, expression of glutathione synthetase, Therapeutics. Pharmacology, Toxicology
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Engineering > Bioengineering
Unknown Department
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Depositing user: Strathprints Administrator
Date Deposited: 04 Oct 2010 18:19
Last modified: 04 Sep 2014 21:08
URI: http://strathprints.strath.ac.uk/id/eprint/9905

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