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A traceless solid-phase synthesis of pteridines

Gibson, C.L. and La Rosa, S. and Suckling, C.J. (2003) A traceless solid-phase synthesis of pteridines. Tetrahedron Letters, 44 (6). pp. 1267-1270. ISSN 0040-4039

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Abstract

The linking of pyrimidines to polystyrene supports via either a 2- or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.

Item type: Article
ID code: 723
Keywords: pyrimidines, polystyrene, oxidative cleavage, Chemistry
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Unknown Department
Related URLs:
    Depositing user: Allison Crawford
    Date Deposited: 05 Apr 2006
    Last modified: 12 Mar 2012 10:35
    URI: http://strathprints.strath.ac.uk/id/eprint/723

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