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Discover Open Access research at Strathprints

It's International Open Access Week, 24-30 October 2016. This year's theme is "Open in Action" and is all about taking meaningful steps towards opening up research and scholarship. The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Explore recent world leading Open Access research content by University of Strathclyde researchers and see how Strathclyde researchers are committing to putting "Open in Action".


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The interaction of hexavalent chromium with mouse macrophages

Lalaouni, A. and Kupper, C. and Grant, M.H. (2002) The interaction of hexavalent chromium with mouse macrophages. Toxicology, 192 (1). p. 86. ISSN 0300-483X

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Many orthopaedic implants are made of stainless steel or cobalt–chrome alloys which degrade in vivo, releasing metal ions and particles into the body. This can lead to loosening of prostheses through local inflammatory processes and toxicity to adjacent tissues. Cr VI is one of the most toxic ions released from metal implants, and concentrations up to 2 mM have been measured in tissues samples adjacent to retrieved implants (Blumenthal et al., 1994). It is well recognised as a carcinogen in man (Langard, 1983) although the mechanism of action is undetermined. In this study Cr VI toxicity to macrophages was assessed in vitro using the J774.1 murine macrophage cell line.