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The interaction of hexavalent chromium with mouse macrophages

Lalaouni, A. and Kupper, C. and Grant, M.H. (2002) The interaction of hexavalent chromium with mouse macrophages. Toxicology, 192 (1). p. 86. ISSN 0300-483X

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Abstract

Many orthopaedic implants are made of stainless steel or cobalt–chrome alloys which degrade in vivo, releasing metal ions and particles into the body. This can lead to loosening of prostheses through local inflammatory processes and toxicity to adjacent tissues. Cr VI is one of the most toxic ions released from metal implants, and concentrations up to 2 mM have been measured in tissues samples adjacent to retrieved implants (Blumenthal et al., 1994). It is well recognised as a carcinogen in man (Langard, 1983) although the mechanism of action is undetermined. In this study Cr VI toxicity to macrophages was assessed in vitro using the J774.1 murine macrophage cell line.

Item type: Article
ID code: 38424
Notes: Selected Papers and Abstracts of the British Toxicology Society Annual Congress, (UMIST)
Keywords: mouse macrophages , hexavalent chromium , toxicology, Chemistry, Bioengineering, Toxicology
Subjects: Science > Chemistry
Technology > Engineering (General). Civil engineering (General) > Bioengineering
Department: Faculty of Engineering > Bioengineering
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 12 Mar 2012 16:02
    Last modified: 04 Sep 2014 19:08
    URI: http://strathprints.strath.ac.uk/id/eprint/38424

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