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Effects of substituting Fructose by Mannitol in a pharmaceutical formulation

Schmidt, E. and Ford, S. and Dooley, N. and Elliot, M. and Halbert, G. (2010) Effects of substituting Fructose by Mannitol in a pharmaceutical formulation. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1428-1429. ISSN 0022-3573

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Abstract

Pharmaceutical formulations can increase the solubility and stability of drug molecules. L-p-10 Boronphenylalanine (BPA) has previously been formulated with Fructose. Here we present a novel BPA formulation with Mannitol resulting in improved kinetic solubility along with the removal of possible Fructose related intolerance reactions.

Item type: Article
ID code: 31392
Keywords: P-boronophenylalanine, complex-formation, monosaccharides, solubility, Pharmacy and materia medica, Pharmaceutical Science, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date Deposited: 24 Jun 2011 10:48
Last modified: 08 Feb 2015 02:08
URI: http://strathprints.strath.ac.uk/id/eprint/31392

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