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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Inflammatory response to orthopaedic cobalt chromium alloy wear debris in a rodent air pouch model

Akbar, M. and Brewer, J.M. and Grant, M.H. (2010) Inflammatory response to orthopaedic cobalt chromium alloy wear debris in a rodent air pouch model. Toxicology Letters, 196S. S199. ISSN 0378-4274

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Abstract

Cobalt chromium (Co-Cr) alloy metal-on-metal (MOM) hip resurfacing has become increasingly common in younger, more active patients. However, there is growing concern regarding levels of Co-Cr wear debris and ions released. Using the rodent air pouch model, described as a facsimile synovium, we assessed the inflammatory response to artificially generated Co-Cr wear debris.