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Superoxide and superoxide dismutase in pulmonary hypoxic vasoconstriction

Milliken, P.H. and Wadsworth, R.M. (2002) Superoxide and superoxide dismutase in pulmonary hypoxic vasoconstriction. Thorax, 57 (Supp.3). p. 75. ISSN 0040-6376

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Abstract

Superoxide is known to cause vascular damage and can consume protective NO that maintains a low pulmonary pressure. There is evidence suggesting that hypoxia upregulates NADH/NADPH oxidase and xanthine oxidase in the smooth muscle and endothelial cells of the pulmonary artery, increasing superoxide production. Superoxide dismutase (SOD) is widely distributed in the cells of the vasculature, destroying superoxide, however, the role of SOD in hypoxic vasoconstriction is unknown.1 Therefore, the effect of endogenous SOD inhibition and superoxide generation on hypoxic pulmonary vasoconstriction was investigated.

Item type: Article
ID code: 22843
Notes: Non-variant with 22982 (text different).
Keywords: superoxide, superoxide dismutase, pulmonary hypoxic vasoconstriction, Therapeutics. Pharmacology, Pulmonary and Respiratory Medicine
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Strathprints Administrator
Date Deposited: 12 Jul 2010 10:16
Last modified: 21 May 2015 12:18
Related URLs:
URI: http://strathprints.strath.ac.uk/id/eprint/22843

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