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Impact of varying intensities of blue-light exposure on 3T3 cells

Smith, S. and Maclean, M. and MacGregor, S.J. and Anderson, J.G. and Grant, M.H. (2009) Impact of varying intensities of blue-light exposure on 3T3 cells. European Cells and Materials, 18 (Suppl.). p. 106. ISSN 1473-2262

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There is the need to develop a compatible sterilisation method for hybrid biomaterials. High-intensity blue light in the 405 nm region has been shown to be an effective bacterial decontamination method [1], to cause no noticeable damage to the gross structure of type-I collagen monomer (when treated at 10 mW/cm2) [2], and to have no noticeable effect on 3T3 cell viability, growth rate, redox state or lactate dehydrogenase (LDH) leakage (at 1.0 mW/cm2) [2]. The purpose of this research was to investigate the effect of varying the blue-light intensity on the 3T3 cell response parameters.