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Long-range surface plasmon resonance imaging for bioaffinity sensing

Wark, A.W. and Lee, H.J. and Corn, R.M. (2005) Long-range surface plasmon resonance imaging for bioaffinity sensing. Analytical Chemistry, 77 (13). pp. 3904-3907. ISSN 0003-2700

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A novel bioaffinity sensor based on surface plasmon resonance (SPR) imaging measurements of a multiple-layered structure that supports the generation of long-range surface plasmons (LRSPs) at the water−metal interface is reported. LRSPs possess longer surface propagation lengths, higher electric field strengths, and sharper angular resonance curves than conventional surface plasmons. LRSPR imaging is a version of SPR imaging that requires a symmetric dielectric arrangement around the gold thin film. This arrangement is created using an SF10 prism/Cytop/gold/water multilayer film structure where Cytop is an amorphous fluoropolymer with a refractive index very close to that of water. LRSPR imaging experiments are performed at a fixed incident angle and lead to an enhanced response for the detection of surface binding interactions. As an example, the hybridization adsorption of a 16-mer single-stranded DNA (ssDNA) onto a two-component ssDNA array was monitored with LRSPR imaging. The ssDNA array was created using a new fabrication technology appropriate for the LRSPR multilayers.

Item type: Article
ID code: 9932
Keywords: surface plasmon resonance, long-range surface plasmons, LRSPs, imaging, bioaffinity sensors, Chemistry, Chemistry (miscellaneous)
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Depositing user: Strathprints Administrator
Date Deposited: 28 Sep 2011 14:17
Last modified: 21 May 2015 10:22

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