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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts

Saddiq, Z.A. and Barbenel, J.C. and Grant, M.H. (2005) The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts. In: Tissue and Cell Engineering Society Meeting, 2005-05-20 - 2005-05-22.

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Abstract

Collagen based scaffolds are widely used for tissue engineering strategies; many are designed to biodegrade gradually and become populated with host cells. The effect of infiltration by host cells on the mechanical properties of the scaffolds is unclear. We have used fibroblast populated collagen lattices to study the effects of the presence of 3T3 mouse fibroblasts on the mechanical properties of collagen gels containing glycosaminoglycans (GAGs) crosslinked with the carbodiimide, 1,1-carbonyldiimidazole (CDI), and the polyamine, putrescine (Put).