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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts

Saddiq, Z.A. and Barbenel, J.C. and Grant, M.H. (2005) The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts. In: Tissue and Cell Engineering Society Meeting, 2005-05-20 - 2005-05-22.

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Abstract

Collagen based scaffolds are widely used for tissue engineering strategies; many are designed to biodegrade gradually and become populated with host cells. The effect of infiltration by host cells on the mechanical properties of the scaffolds is unclear. We have used fibroblast populated collagen lattices to study the effects of the presence of 3T3 mouse fibroblasts on the mechanical properties of collagen gels containing glycosaminoglycans (GAGs) crosslinked with the carbodiimide, 1,1-carbonyldiimidazole (CDI), and the polyamine, putrescine (Put).