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Early experience with a new technique and technology designed for the study of pulsatile cardiopulmonary bypass in the rat

Gourlay, T. and Ballaux, P.K. and Draper, E.R. and Taylor, K.M. (2002) Early experience with a new technique and technology designed for the study of pulsatile cardiopulmonary bypass in the rat. Perfusion, 17 (3). pp. 191-198. ISSN 0267-6591

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Abstract

The benefits of pulsatile flow during the period of cardiopulmonary bypass (CPB) applied during open-heart surgery remains controversial. We have developed a rodent (rat) model of CBP that has been designed to functionally mimic the clinical setting, principally, but not solely, for the study of pulsatile CPB. The successful development of this model centres on the design of the bypass circuitry and the surgical approach employed. The entire circuit is similar to clinical equipment in terms of its construction, configuration, performance, material surface area to blood volume ratio, and priming volume to blood volume ratio. The overall priming volume of the perfusion circuitry is less than 12 ml. Early studies confirm that the pumping technology functions well, gas exchange was adequate at all times, and blood pressure exhibited a normal CPB profile and haemodynamic response to pulsatile blood flow. We conclude that this is an effective tool for investigating the pathophysiology of pulsatile blood flow during CPB.

Item type: Article
ID code: 8236
Keywords: pulsatile cardiopulmonary bypass, rat, bypass surgery, cardiopulmonary bypass, Bioengineering, Surgery, Health Professions (miscellaneous), Cardiology and Cardiovascular Medicine, Medicine (miscellaneous)
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Medicine > Surgery
Department: Faculty of Engineering > Bioengineering
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 06 Aug 2009 14:50
    Last modified: 03 Jul 2014 15:57
    URI: http://strathprints.strath.ac.uk/id/eprint/8236

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