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Lymphocyte tracking and interactions in secondary lymphoid organs

Brewer, J.M. and Millington, O.R. and Zinselmeyer, B.H. and Garside, P. and Rush, C. (2007) Lymphocyte tracking and interactions in secondary lymphoid organs. Inflammation Research, 56 (10). pp. 391-401. ISSN 1023-3830

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Abstract

The induction of an adaptive immune response is an essential step in the generation of long-lasting, protective immunity to pathogens. Many studies over the last few decades have identified the cell populations involved in the generation of antigen-specific immunity and elucidated the role of many important molecules. However, because of the low precursor frequency of antigen-specific cells, the immune system must be highly dynamic, surveying most sites of the body. Recent studies have, therefore, begun to examine how the cells of the immune system interact in vivo during the induction of an immune response, identifying new and important roles for certain molecules and revealing how previously unrecognised alterations in cell-cell interactions can have significant implications for the resulting immune response. Here we review some of these recent studies that provide a valuable insight into the mechanisms involved in the induction of immunity.

Item type: Article
ID code: 7620
Keywords: lymphocyte tracking, secondary lymphoid organs, physiology, biomedical sciences, biophotonics, Pharmacy and materia medica, Physiology, Immunology, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Science > Physiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Centre for Biophotonics
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 06 Mar 2009 16:42
    Last modified: 04 Sep 2014 17:36
    URI: http://strathprints.strath.ac.uk/id/eprint/7620

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