Picture of scraped petri dish

Scrape below the surface of Strathprints...

Explore world class Open Access research by researchers at the University of Strathclyde, a leading technological university.

Explore

Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells

Millington, O.R. and Gibson, Vivienne B. and Rush, C. and Zinselmeyer, B.H. and Phillips, R.S. and Garside, P. and Brewer, J.M. (2007) Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells. PLOS Pathogens, 3 (10). e143. ISSN 1553-7366

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens are reduced. Here, we demonstrate that malaria infection or the parasite pigment hemozoin inhibits T cell and DC interactions both in vitro and in vivo, while signal 1 intensity remains unaltered. This altered cellular behaviour is associated with the suppression of DC costimulatory activity and functional T cell responses, potentially explaining why immunity is reduced during malaria infection.