Picture of virus under microscope

Research under the microscope...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

Explore SIPBS research

Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells

Millington, O.R. and Gibson, Vivienne B. and Rush, C. and Zinselmeyer, B.H. and Phillips, R.S. and Garside, P. and Brewer, J.M. (2007) Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells. PLOS Pathogens, 3 (10). e143. ISSN 1553-7366

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens are reduced. Here, we demonstrate that malaria infection or the parasite pigment hemozoin inhibits T cell and DC interactions both in vitro and in vivo, while signal 1 intensity remains unaltered. This altered cellular behaviour is associated with the suppression of DC costimulatory activity and functional T cell responses, potentially explaining why immunity is reduced during malaria infection.