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Perfusion based microfluidic system for pharmacological profiling of neuronal networks

MacKerron, C. and Robertson, G. and Bushell, T.J. and Zagnoni, M. (2016) Perfusion based microfluidic system for pharmacological profiling of neuronal networks. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Chemical and Biological Microsystems Society, San Diego, CA, pp. 445-446. ISBN 9781510834163

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This work presents the integration of a semi-automated microfluidic platform that utilizes calcium imaging to enable the pharmacological characterization of functionally connected, but environmentally isolated neuronal networks. This approach allows, for the first time, to assess the cause-effect relationship of neuronal communication following drug application, thus allowing the pharmacological characterisation of novel drugs proposed to influence communication between neuronal networks.