Picture of person typing on laptop with programming code visible on the laptop screen

World class computing and information science research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.


Perfusion based microfluidic system for pharmacological profiling of neuronal networks

MacKerron, C. and Robertson, G. and Bushell, T.J. and Zagnoni, M. (2016) Perfusion based microfluidic system for pharmacological profiling of neuronal networks. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Chemical and Biological Microsystems Society, San Diego, CA, pp. 445-446. ISBN 9781510834163

Text (MacKerron-etal-MicroTAS2016-Perfusion-based-microfluidic-system-for-pharmacological)
MacKerron_etal_MicroTAS2016_Perfusion_based_microfluidic_system_for_pharmacological.pdf - Accepted Author Manuscript

Download (236kB) | Preview


This work presents the integration of a semi-automated microfluidic platform that utilizes calcium imaging to enable the pharmacological characterization of functionally connected, but environmentally isolated neuronal networks. This approach allows, for the first time, to assess the cause-effect relationship of neuronal communication following drug application, thus allowing the pharmacological characterisation of novel drugs proposed to influence communication between neuronal networks.