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Polymer templating of supercooled indomethacin for polymorph selection

McKellar, Scott C and Urquhart, Andrew J and Lamprou, Dimitrios A and Florence, Alastair J (2012) Polymer templating of supercooled indomethacin for polymorph selection. ACS Combinatorial Science, 14 (3). pp. 155-159. ISSN 2156-8944

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Abstract

Reported here is a relatively simple technique for polymorph screening of pharmaceutical compounds that are thermally stable. Polymer libraries have previously been used as surfaces to influence, or direct, the crystalline form adopted by an active pharmaceutical ingredient on crystallization from solution. In this current work, we demonstrate the polymorph-directing effect of homopolymer surfaces in the absence of solvent by recrystallization from the supercooled melt. When the nonsteroidal anti-inflammatory drug indomethacin is melted, cooled, and subsequently reheated above its glass transition temperature on an untreated surface, it has a proclivity to crystallize as its δ polymorph. On certain polymer surfaces, however, it preferentially crystallizes as the α polymorph, as a direct result of polymer templating. The method is well-suited to implementation in multiwell plate formats requiring only small amounts of material and enabling multiple experiments to be carried out in parallel with samples readily characterized using X-ray powder diffraction.

Item type: Article
ID code: 40714
Keywords: indomethacin, polymorph screening, polymer templating, polymer-induced, heteronucleation, glass transition, Pharmacy and materia medica, Chemistry(all)
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Bionanotechnology
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
Related URLs:
Depositing user: Pure Administrator
Date Deposited: 03 Aug 2012 10:15
Last modified: 27 Mar 2014 10:24
URI: http://strathprints.strath.ac.uk/id/eprint/40714

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