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Pre-clinical bioimaging in a mouse model of rheumatoid arthritis

Ierna, Michelle and Smith, Karen and Ross, Kirsty and Meiklejohn, Gordon and Maffia, Pasquale and Brewer, James M. and McInnes, Iain B. and Garside, Paul (2011) Pre-clinical bioimaging in a mouse model of rheumatoid arthritis. Arthritis and Rheumatism, 63 (10). S75-S75. ISSN 0004-3591

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Abstract

The early detection of changes to molecular pathways underlying Rheumatoid Arthritis (RA) is a key goal in Rheumatology. However, the standard disease scoring methods employed in the standard mouse model of RA, Collagen Induced Arthritis (CIA) cannot adequately quantify cellular or molecular processes. Here, we show that biofluorescence imaging can track in vivo processes contributing to disease and allow comparisons to be made of therapeutic drug efficacy earlier in disease progression.