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Computational methodologies for modelling, analysis and simulation of signalling networks

Gilbert, David and Fuss, H. and Gu, Xu and Orton, Richard and Robinson, S. and Vyshemirsky, Vladislav and Kurth, M. J. and Downes, C. S. and Dubitzky, W. (2006) Computational methodologies for modelling, analysis and simulation of signalling networks. Briefings in Bioinformatics. pp. 339-353. ISSN 1467-5463

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Abstract

his article is a critical review of computational techniques used to model, analyse and simulate signalling networks. We propose a conceptual framework, and discuss the role of signalling networks in three major areas: signal transduction, cellular rhythms and cell-to-cell communication. In order to avoid an overly abstract and general discussion, we focus on three case studies in the areas of receptor signalling and kinase cascades, cell-cycle regulation and wound healing. We report on a variety of modelling techniques and associated tools, in addition to the traditional approach based on ordinary differential equations (ODEs), which provide a range of descriptive and analytical powers. As the field matures, we expect a wider uptake of these alternative approaches for several reasons, including the need to take into account low protein copy numbers and noise and the great complexity of cellular organisation. An advantage offered by many of these alternative techniques, which have their origins in computing science, is the ability to perform sophisticated model analysis which can better relate predicted behaviour and observations.

Item type: Article
ID code: 37076
Keywords: systems biology, computational biology, modelling , Probabilities. Mathematical statistics, Molecular Biology, Information Systems
Subjects: Science > Mathematics > Probabilities. Mathematical statistics
Department: Faculty of Science > Mathematics and Statistics
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 25 Jan 2012 15:44
    Last modified: 05 Sep 2014 13:57
    URI: http://strathprints.strath.ac.uk/id/eprint/37076

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