Italia, Jagdishbhai L and Sharp, Andrew and Carter, Katharine C and Warn, Peter and Kumar, M N V Ravi (2011) Peroral amphotericin B polymer nanoparticles lead to comparable or superior in vivo antifungal activity to that of intravenous Ambisome® or Fungizone™. PLoS One, 6 (10). e25744.
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1371/journal.pone.0025744
Abstract
Despite advances in the treatment, the morbidity and mortality rate associated with invasive aspergillosis remains unacceptably high (70-90%) in immunocompromised patients. Amphotericin B (AMB), a polyene antibiotic with broad spectrum antifungal activity appears to be a choice of treatment but is available only as an intravenous formulation; development of an oral formulation would be beneficial as well as economical.
| Item type: | Article |
|---|---|
| ID code: | 36463 |
| Keywords: | polymer nanoparticles, antifungal activity , amphotericin B polymer nanoparticles, Therapeutics. Pharmacology |
| Subjects: | Medicine > Therapeutics. Pharmacology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences ?? 120 ?? |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 16 Dec 2011 05:21 |
| Last modified: | 12 Jun 2013 14:34 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/36463 |
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