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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

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Tritium labeling of the PXR ligand GW5801 - an unexpected tritium exchange reaction

Chappelle, Michael R. and Morgan, Alan D. and Tomkinson, Nicholas C. O. and Willson, Timothy M. (2001) Tritium labeling of the PXR ligand GW5801 - an unexpected tritium exchange reaction. In: Synthesis and applications of isotopically labelled compounds, volume 7. Wiley-Blackwell, pp. 80-83. ISBN 0471495018

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Abstract

H-T exchange on 4,3,5-HO(Me3C)2C6H2CHO in presence of Crabtree's catalyst gave exclusively 4,3,5-HO(Me3C)2C6H2CTO, which was treated with CH2[P(O)(OEt)2]2 to give 4,3,5-HO(Me3C)2C6H2CT:CH[P(O)(OEt)2]2. The absence of ring tritiation in 4,3,5-HO(Me3C)2C6H2CHO is attributed to steric hindrance by the tert.-Bu groups. [on SciFinder(R)]