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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Towards the total synthesis of Agariblazeispirol C.

Paterson, Laura C. and Kerr, William J. and Sutherland, Andrew. (2009) Towards the total synthesis of Agariblazeispirol C. In: WestCHEM Postgraduate Symposium in Organic Chemistry, 2009-06-19.

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Abstract

Efforts within our lab. have focused towards the synthesis of Agariblazeispirol C, 1, which was recently isolated from the cultured mycelia of Agaricus blazei. Our proposed pathway for gaining access to Agariblazeispirol C centers on the strategic employment of metal-mediated cyclisation chem. Specifically, an . Pauson-Khand reaction (PKR) will be used to construct the C/D ring section of the natural target, and a novel intramol. Heck reaction will establish the key all carbon quaternary center between rings B and C.