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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

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Towards the total synthesis of Agariblazeispirol C.

Paterson, Laura C. and Kerr, William J. and Sutherland, Andrew. (2009) Towards the total synthesis of Agariblazeispirol C. In: WestCHEM Postgraduate Symposium in Organic Chemistry, 2009-06-19.

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Abstract

Efforts within our lab. have focused towards the synthesis of Agariblazeispirol C, 1, which was recently isolated from the cultured mycelia of Agaricus blazei. Our proposed pathway for gaining access to Agariblazeispirol C centers on the strategic employment of metal-mediated cyclisation chem. Specifically, an . Pauson-Khand reaction (PKR) will be used to construct the C/D ring section of the natural target, and a novel intramol. Heck reaction will establish the key all carbon quaternary center between rings B and C.