Stone, Nicholas and Kerssens, Marleen and Lloyd, Gavin Rhys and Faulds, Karen and Graham, Duncan and Matousek, Pavel (2011) Surface enhanced spatially offset Raman spectroscopic (SESORS) imaging - the next dimension. Chemical Science, 2 (4). pp. 776-780. ISSN 2041-6520Full text not available in this repository. (Request a copy from the Strathclyde author)
SESORS - Surface enhanced spatially offset Raman spectroscopy-imaging is explored for the first time in this study. Multiplexed surface enhanced Raman scattering (SERS) signals have been recovered non-invasively from a depth of 20 mm in tissues for the first time and reconstructed to produce a false colour image. Four unique 'flavours' of SERS nanoparticles (NPs) were injected into a 20 x 50 x 50 mm porcine tissue block at the corners of a 10 mm square. A transmission Raman data cube was acquired over an 11 x 11 pixel grid made up of 2 mm steps. The signals were reconstructed using the unique peak intensities of each of the nanoparticles. A false colour image of the relative signal levels was produced, demonstrating the capability of multiplexed imaging of SERS nanoparticles using deep Raman spectroscopy. A secondary but no less significant achievement was to demonstrate that Raman signals from SERS nanoparticles can be recovered non-invasively from samples of the order of 45-50 mm thick. This is a significant step forward in the ability to detect and identify vibrational fingerprints within tissue and offers the opportunity to adapt these particles and this approach into a clinical setting for disease diagnosis.
|Keywords:||silver electrode, raman scattering, sers, tissue, media, antibodies, TIC - Bionanotechnology, Physical and theoretical chemistry|
|Subjects:||Science > Chemistry > Physical and theoretical chemistry|
|Department:||Faculty of Science > Pure and Applied Chemistry|
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|Depositing user:||Pure Administrator|
|Date Deposited:||17 Oct 2011 14:45|
|Last modified:||12 Jun 2013 14:32|
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