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The potential of cucurbit[n]urils in drug delivery

Walker, Shonagh and Oun, Rabbab and Mcinnes, Fiona and Wheate, Nial (2011) The potential of cucurbit[n]urils in drug delivery. Israel Journal of Chemistry, 51 (5-6). pp. 616-624. ISSN 1869-5868

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Abstract

In this paper we review cucurbit[n]urils (CB[n]), a relatively new family of macrocycles that has shown potential in improving drug delivery. Encapsulation of drugs within the homologues CB[6], CB[7], or CB[8] can impart enhanced chemical and physical stability, improve drug solubility, and control drug release. The formulation of CB[n] into a dosage form suitable for clinical use is a non-trivial task, because the free macrocycle and its host-drug complex generally exhibit pseudo-polymorphism in the solid state. Despite this, cucurbiturils have been included in tablets for oral delivery and inserts for nasal delivery. Here we examine the potential use of cucurbiturils in drug delivery in the context of getting a new drug into clinical trials and discuss what further research is needed in this area.

Item type: Article
ID code: 32448
Keywords: cucurbituril, drug delivery, formulation, polymorphism, solubility, stability, Pharmacy and materia medica, Chemistry(all)
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Pure Administrator
Date Deposited: 05 Aug 2011 14:57
Last modified: 05 Sep 2014 10:06
URI: http://strathprints.strath.ac.uk/id/eprint/32448

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