Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells : role of sphingosine kinase 1 and S1P lyase

Berdyshev, Evgeny V and Gorshkova, Irina and Usatyuk, Peter and Kalari, Satish and Zhao, Yutong and Pyne, Nigel J and Pyne, Susan and Sabbadini, Roger A and Garcia, Joe G.N. and Natarajan, Viswanathan (2011) Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells : role of sphingosine kinase 1 and S1P lyase. PLoS One, 6 (1). e16571.

[img] PDF (Berdyshev_etal_PLoSOne2011) - Published Version
Available under License Creative Commons Attribution.

Download (3077Kb)

    Abstract

    Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade. As endothelial cells generate intracellular S1P, here we have investigated the role of sphingosine kinases (SphKs) and S1P lyase (S1PL), that regulate intracellular S1P accumulation, in HPAEC motility.

    Item type: Article
    ID code: 32345
    Keywords: human lung endothelial cells, S1P generation, endothelial cell motility , Pharmacy and materia medica, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Medicine(all)
    Subjects: Medicine > Pharmacy and materia medica
    Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 28 Jul 2011 16:32
    Last modified: 27 Mar 2014 21:10
    URI: http://strathprints.strath.ac.uk/id/eprint/32345

    Actions (login required)

    View Item

    Fulltext Downloads: