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Toxoplasma gondii tachyzoite-bradyzoite interconversion

Lyons, Russell E and McLeod, Rima and Roberts, Craig W (2002) Toxoplasma gondii tachyzoite-bradyzoite interconversion. Trends in Parasitology, 18 (5). pp. 198-201. ISSN 1471-4922

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Abstract

During infection in the intermediate host, Toxoplasma gondii undergoes stage conversion between the rapidly dividing tachyzoite that is responsible for acute toxoplasmosis and the slowly replicating, encysted bradyzoite stage. This process of tachyzoite-bradyzoite interconversion is central to the pathogenesis and longevity of infection. Recent research has identified several stage-specific genes and proteins. However, despite recent advances in the understanding of Toxoplasma cell biology, more research is necessary to elucidate the complex events occurring during tachyzoite-bradyzoite interconversion. Here, a brief summary of this process is provided and a new method to characterize gene expression during interconversion is introduced.

Item type: Article
ID code: 31731
Keywords: tissue cyst formation, molecular-cloning, stage converstion, differential expression, targeted disruption, gene, antigen, surface, induction, enzymes, Pharmacy and materia medica, Infectious Diseases, Parasitology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Immunology
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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    Depositing user: Pure Administrator
    Date Deposited: 13 Jul 2011 09:57
    Last modified: 04 Apr 2014 16:34
    URI: http://strathprints.strath.ac.uk/id/eprint/31731

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