Pyne, N.J. and Pyne, S. (2010) Sphingosine 1-phosphate and cancer. Nature Reviews Cancer, 10 (7). pp. 489-503. ISSN 1474-175X
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1038/nrc2875
Abstract
There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival. This occurs at multiple levels and involves S1P receptors, sphingosine kinases, S1P phosphatases and S1P lyase. This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer.
| Item type: | Article |
|---|---|
| ID code: | 28084 |
| Keywords: | sphingosine 1-phosphate, cancer, neovascularization, inflammation, Immunology, Therapeutics. Pharmacology, Neoplasms. Tumors. Oncology (including Cancer) |
| Subjects: | Science > Microbiology > Immunology Medicine > Therapeutics. Pharmacology Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer) |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Miss Shauna Thompson |
| Date Deposited: | 13 Oct 2010 12:32 |
| Last modified: | 05 Oct 2012 20:59 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/28084 |
Actions (login required)
| View Item |