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Modelling drug-eluting stents

McGinty, Sean and Mckee, Sean and Wadsworth, Roger and McCormick, Christopher (2010) Modelling drug-eluting stents. Mathematical Medicine and Biology, 28 (1). pp. 1-29. ISSN 0265-0746

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Abstract

In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque. We investigate the relative importance of transmural convection, diffusion and drug-dependent parameters in drug delivery and deposition. Furthermore, we investigate how the release rate from the stent can be altered and examine the resulting effect on cellular drug concentrations.

Item type: Article
ID code: 26084
Notes: AHR
Keywords: drug-eluting stents, Laplace transforms, sensitivity analysis, Probabilities. Mathematical statistics, Therapeutics. Pharmacology, Neuroscience(all), Biochemistry, Genetics and Molecular Biology(all), Environmental Science(all), Modelling and Simulation, Applied Mathematics, Immunology and Microbiology(all), Pharmacology
Subjects: Science > Mathematics > Probabilities. Mathematical statistics
Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Mathematics and Statistics
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Engineering > Bioengineering
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Depositing user: Strathprints Administrator
Date Deposited: 20 Sep 2010 11:28
Last modified: 05 Sep 2014 06:45
URI: http://strathprints.strath.ac.uk/id/eprint/26084

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