Mcginty, Sean and Mckee, Sean and Wadsworth, Roger and McCormick, Christopher (2010) Modelling drug-eluting stents. IMA Journal of Mathematics Applied in Medicine and Biology, 28 (1). pp. 1-29. ISSN 1477-8599
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque. We investigate the relative importance of transmural convection, diffusion and drug-dependent parameters in drug delivery and deposition. Furthermore, we investigate how the release rate from the stent can be altered and examine the resulting effect on cellular drug concentrations.
| Item type: | Article |
|---|---|
| ID code: | 26084 |
| Notes: | AHR |
| Keywords: | drug-eluting stents, Laplace transforms, sensitivity analysis, Probabilities. Mathematical statistics, Therapeutics. Pharmacology |
| Subjects: | Science > Mathematics > Probabilities. Mathematical statistics Medicine > Therapeutics. Pharmacology |
| Department: | Faculty of Science > Mathematics and Statistics Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Engineering > Bioengineering |
| Related URLs: | |
| Depositing user: | Strathprints Administrator |
| Date Deposited: | 20 Sep 2010 11:28 |
| Last modified: | 04 Oct 2012 13:29 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/26084 |
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