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Disrupted-in-Schizophrenia-1

Muir, W.J. and Pickard, B.S. and Blackwood, D.H.R. (2008) Disrupted-in-Schizophrenia-1. Current Psychiatry Reports, 10 (2). pp. 140-147. ISSN 1523-3812

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Abstract

Chromosomal abnormalities can be powerful tools to identify genes that influence disease risk. The study of a chromosome translocation that segregated with severe psychiatric illness in a large family led directly to the discovery of a gene disrupted by a chromosomal breakpoint. Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders. We review the work that led up to this discovery and the evidence that it is important in the wider population with schizophrenia and affective disorders. We also discuss the latest findings on the neuronal functions of the protein DISC1 encoded by the gene.

Item type: Article
ID code: 25911
Keywords: chromosomal abnormalities, genes, disease risk, chromosome translocation, psychiatric illness, Disrupted-in-Schizophrenia-1, DISC1, schizophrenia, Other systems of medicine, Pharmacy and materia medica
Subjects: Medicine > Other systems of medicine
Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 20 Aug 2010 11:44
    Last modified: 04 Oct 2012 13:20
    URI: http://strathprints.strath.ac.uk/id/eprint/25911

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