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Muir, W.J. and Pickard, B.S. and Blackwood, D.H.R. (2008) Disrupted-in-Schizophrenia-1. Current Psychiatry Reports, 10 (2). pp. 140-147. ISSN 1523-3812

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Chromosomal abnormalities can be powerful tools to identify genes that influence disease risk. The study of a chromosome translocation that segregated with severe psychiatric illness in a large family led directly to the discovery of a gene disrupted by a chromosomal breakpoint. Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders. We review the work that led up to this discovery and the evidence that it is important in the wider population with schizophrenia and affective disorders. We also discuss the latest findings on the neuronal functions of the protein DISC1 encoded by the gene.

Item type: Article
ID code: 25911
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Keywords: chromosomal abnormalities, genes, disease risk, chromosome translocation, psychiatric illness, Disrupted-in-Schizophrenia-1, DISC1, schizophrenia, Other systems of medicine, Pharmacy and materia medica, Psychiatry and Mental health
Subjects: Medicine > Other systems of medicine
Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Strathprints Administrator
Date Deposited: 20 Aug 2010 10:44
Last modified: 10 Dec 2015 19:20

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