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Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma

Liu, Manjuan and Katerere, David R. and Gray, Alexander I. and Seidel, Veronique (2009) Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma. Fitoterapia, 80 (6). pp. 369-373. ISSN 0367-326X

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Abstract

Phytochemical investigation of the stem bark of Terminalia mollis afforded friedelin (1), catechin with epicatechin (2), gallocatechin with epigallocatechin (3) and 3-O-methylellagic acid 4'-O-alpha-rhamnopyranoside (4). Arjunolic acid with 2 alpha, 3 beta, 23-trihydroxy-urs-12-en-28-oic acid (5), 2 alpha-hydroxyursolic acid (6), gallic acid (7), chebulanin (8) and 2 ''-O-galloylvitexin (9) were isolated from the leaf. Chebulanin (8), betulinic acid (10), ursolic acid (11), catechin (12), isoorientin (13), orientin (14), isovitexin (15) and punicalagin (16) were isolated from Terminalia brachystemma leaf The first full unambiguous NMR assignments for (4) and (8), and revised assignments for (9), are reported. Compound (16) showed good activity against three Candida species.