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Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma

Liu, Manjuan and Katerere, David R. and Gray, Alexander I. and Seidel, Veronique (2009) Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma. Fitoterapia, 80 (6). pp. 369-373. ISSN 0367-326X

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Abstract

Phytochemical investigation of the stem bark of Terminalia mollis afforded friedelin (1), catechin with epicatechin (2), gallocatechin with epigallocatechin (3) and 3-O-methylellagic acid 4'-O-alpha-rhamnopyranoside (4). Arjunolic acid with 2 alpha, 3 beta, 23-trihydroxy-urs-12-en-28-oic acid (5), 2 alpha-hydroxyursolic acid (6), gallic acid (7), chebulanin (8) and 2 ''-O-galloylvitexin (9) were isolated from the leaf. Chebulanin (8), betulinic acid (10), ursolic acid (11), catechin (12), isoorientin (13), orientin (14), isovitexin (15) and punicalagin (16) were isolated from Terminalia brachystemma leaf The first full unambiguous NMR assignments for (4) and (8), and revised assignments for (9), are reported. Compound (16) showed good activity against three Candida species.

Item type: Article
ID code: 19022
Keywords: terminalia mollis, terminalia brachystemma, combretaceae, punicalagin, antifungal activity, Pharmacy and materia medica, Drug Discovery, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Strathprints Administrator
Date Deposited: 25 May 2010 09:01
Last modified: 27 Jan 2016 11:19
Related URLs:
URI: http://strathprints.strath.ac.uk/id/eprint/19022

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