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Comparison of PAM and CEA as detectors of mammary micrometastases

Anderson, J.M. and Jhunjhunwala, S.K. and Ewan, J.M. and Stimson, W.H. and Gettinby, G. (1979) Comparison of PAM and CEA as detectors of mammary micrometastases. British Journal of Cancer, 40 (2). p. 320. ISSN 0007-0920

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Abstract

Nineteen of 61 Stage I or II mammary-cancer bearers developed conventionally detectable metastases within 8-44 (median 15) months of commencing follow-up. Serum pregnancy-associated macroglobulin (PAM, PAG, O2 PAG) rose by > 75% above baseline values before detection of metastases in all but 4 of these 19 patients and in 11/42 remaining well. The means of the maximum percentage rises in PAM were 286 for the metastatic and 67 for the well patients (P<0-01 in a Mann-Whitney U-test).