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Comparison of different methods of intracerebral administration of radioiododeoxyuridine for glioma therapy using a rat model

Mairs, R.J. and Wideman, C.L. and Angerson, W.J. and Whateley, T.L. and Reza, M.S. and Reeves, J.R. and Robertson, L.M. and Neshasteh-Riz, A. (2000) Comparison of different methods of intracerebral administration of radioiododeoxyuridine for glioma therapy using a rat model. British Journal of Cancer, 82 (1). pp. 74-80. ISSN 0007-0920

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Abstract

As part of an NHS Executive Trent regional initiative we considered the role and cost-effectiveness of high dose chemotherapy in the treatment of relapsed Hodgkin's disease and non-Hodgkin's lymphoma. The key trials and case series show an additional patient benefit of 0.8-1.1 life years over standard chemotherapy. We estimate incremental cost per life year gained of £12 800-£17 600, which reduces further if long-term benefits are considered. High dose chemotherapy in these conditions is both life-saving and cost-effective.