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Functionalized nanoparticles for bioanalysis by SERRS

Graham, D. and Faulds, Karen and Thompson, David and McKenzie, Fiona and Stokes, Robert J. and Dalton, Colette and Stevenson, Ross and Alexander, J. and Garside, Paul and McFarlane, Emma (2009) Functionalized nanoparticles for bioanalysis by SERRS. Biochemical Society Transactions, 37. pp. 697-701. ISSN 0300-5127

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Abstract

Metallic nanoparticles can be used as basic materials for a wide variety of purposes including building blocks for nanoassemblies, substrates for enhanced spectroscopies such as fluorescence and Raman and as labels for biomolecules. In the present paper, we report how silver and gold nanoparticles can be functionalized with specific biomolecular probes to interact in a specific manner with a target molecule to provide a change in the properties of the nanoparticles which can be measured to indicate the molecular recognition event. Examples of this approach include DNA hybridization to switch on SERRS (surface-enhanced resonance Raman scattering) when a specific target sequence is present, the use of nanoparticles for in vivo SERRS imaging and the use of nanoparticles functionalized with antibodies to provide a new type of immunoassay. These examples indicate how nanoparticles can be used to provide highly sensitive and informative data from a variety of biological systems when used in combination with SERRS.

Item type: Article
ID code: 13172
Keywords: bioanalysis, functionalized nanoparticle, immunoassay, metal surface, surface-enhanced resonance Raman scattering (SERRS), surface plasmon resonance (SPR), Physical and theoretical chemistry, Biochemistry
Subjects: Science > Chemistry > Physical and theoretical chemistry
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Pure and Applied Chemistry
Related URLs:
Depositing user: Ms Ann Barker-Myles
Date Deposited: 07 Oct 2009 15:43
Last modified: 28 Mar 2014 05:11
URI: http://strathprints.strath.ac.uk/id/eprint/13172

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