Liu, T.Y. and Jia, J.F. and Wang, H. and Yue, H. (2007) Estimate parameters and states of signalling pathways with unscented kalman filter. Acta Biophysica Sinica, 23 (1). pp. 54-66.Full text not available in this repository. (Request a copy from the Strathclyde author)
One object of systems biology is to develop the mathematical models of biochemical networks in cell and to analysis the system dynamic properties based on these models as well as to predict the system output. However, strong nonlinearity, complexity, noisy and incomplete measurements make the parameter estimation more difficult. In this paper, Unscented Kalman filter was proposed to estimate the unknown parameters and the unobservable state variables simultaneously. TNFα mediated NF-κB signal transduction pathway was taken as an example to illustrate the effectiveness of the method. Simulation results are encouraging and show that both parameters and unobservable state variables can be estimated well.
|Keywords:||systems biology , biochemical networks, cells, unscented Kalman filter, Electrical engineering. Electronics Nuclear engineering|
|Subjects:||Technology > Electrical engineering. Electronics Nuclear engineering|
|Department:||Faculty of Engineering > Electronic and Electrical Engineering|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||16 Nov 2011 16:24|
|Last modified:||11 Sep 2016 00:02|