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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

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Directed meta-metalation using alkali-metal-mediated zincation

Mulvey, R.E. and Armstrong, David R. and Clegg, W. and Hevia, E. and Dale, S.H. and Hogg, L.M. and Honeyman, G.W. (2006) Directed meta-metalation using alkali-metal-mediated zincation. Angewandte Chemie, 45. pp. 3775-3778.

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Abstract

Transforming a carbon–hydrogen bond of an organic compound into a more useful, more reactive carbon–metal bond (so-called deprotonative metalation), which, in turn, can be treated with an electrophile to create a new carbon–carbon or carbon–heteroatom bond, is one of the most fundamental synthetic approaches that chemists employ to construct compounds.[1, 2] Many of these reactions involve a special type of deprotonative metalation, in which an activating functional group is positioned adjacent to the hydrogen atom (strictly a proton) that is to be replaced by the metal cation.