Ensemble and single particle analysis of doxorubicin silk nanoparticles

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Roamcharern, Napaporn and Punnabhum, Panida and Graham, Harriet and Seib, F. Philipp and Rattray, Zahra (2026) Ensemble and single particle analysis of doxorubicin silk nanoparticles. Chemical Communications. ISSN 1364-548X (In Press)

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Abstract

Adsorption-loaded silk nanoparticles exploit protein electrostatics and β-sheet-rich architecture to achieve high doxorubicin loading and pH-responsive release, while preserving silk structure. Ensemble and single-particle analyses reveal exceptional formulation uniformity, while in vitro studies confirm preserved cytotoxicity against MDA-MB-231 human breast cancer cells.

ORCID iDs

Roamcharern, Napaporn ORCID logoORCID: https://orcid.org/0009-0002-2003-1093, Punnabhum, Panida ORCID logoORCID: https://orcid.org/0009-0002-6830-1072, Graham, Harriet ORCID logoORCID: https://orcid.org/0000-0003-2311-592X, Seib, F. Philipp ORCID logoORCID: https://orcid.org/0000-0002-1955-1975 and Rattray, Zahra ORCID logoORCID: https://orcid.org/0000-0002-8371-8549;
CORE (COnnecting REpositories)