Cyclodextrin-siderophore conjugates as a Trojan horse strategy for bacterial targeting

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Ragusa, Chiara and Panebianco, Roberta and Paratore, Vincenzo and Condorelli, Guglielmo Guido and Eskandari, Kaveh and Robinson, Douglas and Scott, Fraser J. and Inturri, Rosanna and Rossitto, Maria Serena and Giglio, Valentina and Vecchio, Graziella (2026) Cyclodextrin-siderophore conjugates as a Trojan horse strategy for bacterial targeting. Journal of Inorganic Biochemistry, 279. 113271. ISSN 0162-0134 (https://doi.org/10.1016/j.jinorgbio.2026.113271)

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Abstract

The rise of antibiotic resistance necessitates the development of innovative strategies to enhance the effectiveness of existing treatments. One promising approach leverages bacterial iron acquisition systems through siderophore-based drug delivery to increase intracellular drug concentrations, a Trojan horse strategy. We synthesized new cyclodextrin conjugates with siderophores, such as deferoxamine and gallic acid, to exploit the cyclodextrin drug inclusion capability within the Trojan horse strategy. These novel derivatives were investigated as doxycycline carriers in the bacteria Escherichia coli and Staphylococcus aureus. Notably, the cyclodextrin deferoxamine derivative significantly enhanced the doxycycline efficacy by a 4-fold improvement of its minimal inhibitory concentration against Escherichia coli.

ORCID iDs

Ragusa, Chiara, Panebianco, Roberta, Paratore, Vincenzo, Condorelli, Guglielmo Guido, Eskandari, Kaveh, Robinson, Douglas ORCID logoORCID: https://orcid.org/0009-0009-1486-0072, Scott, Fraser J. ORCID logoORCID: https://orcid.org/0000-0003-0229-3698, Inturri, Rosanna, Rossitto, Maria Serena, Giglio, Valentina and Vecchio, Graziella;
  • Item type:Article
    ID code:95991
    Dates:
    Date
    Event
    1 June 2026
    Published
    21 February 2026
    Published Online
    16 February 2026
    Accepted
    13 January 2026
    Submitted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:13 Apr 2026 08:20
    Last modified:08 Jun 2026 18:28
    URI:https://strathprints.strath.ac.uk/id/eprint/95991
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