Colour of medicines and children’s acceptability : What children think of the colour of oral dosage forms?

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Alessandrini, Elisa and Gizurarson, Sveinbjorn and Walsh, Jennifer and Turner, Roy and Schaufelberger, Daniel and Iurian, Sonia and Batchelor, Hannah and Klein, Sandra and Nafria, Begonya and Dicks, Pamela and Gaillard, Segolene and Franz, Axel R. and Albano, Jasmin and Wisniewski, Aleksander and Vermehren, Charlotte and Gade, Christina and Andersen, Jon Traerup and Tuleu, Catherine (2026) Colour of medicines and children’s acceptability : What children think of the colour of oral dosage forms? Frontiers in Drug Delivery, 6. 1744120. ISSN 2674-0850 (https://doi.org/10.3389/fddev.2026.1744120)

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Abstract

Background Colour plays an important role in shaping consumer experiences, and in the context of medicines, it may influence patients’ expectations, behaviours, and treatment adherence. There is limited research on how children respond to medicine colour, despite their increased sensitivity to sensory cues. A previous literature review indicated that colour may affect medicine acceptability in children but highlighted the need for further research. This cross-sectional study aimed to fill that gap by directly collecting children’s opinions on the colour of oral medicines through an online survey, targeting a diverse paediatric population across age, health status, and countries in Europe. Methods The survey, developed by UCL School of Pharmacy UCL REC (ID 26765/001) and reviewed by experts of the European Young Persons Advisory Group Network (eYPAGnet), was translated into five languages and distributed via QR codes and anonymous links. Response collection occurred between September 2024 and April 2025. Participants included children aged 3 to 18, with parental assistance when needed and parental consent. Responses were analysed using the software R Studio. Results Out of 669 people who accessed the survey, 382 completed it. For liquids, pink (23%), colourless (16.5%), and blue (15.2%) were most preferred. Reasons included appealing look and taste associations (e.g., strawberry for pink). For solids, white (29.1%), pink (18%), and blue (12.5%) led, with neutral appearance and berry-related flavours cited. Statistically significant gender and age differences in preferences emerged, while variations by health, or country were not always significant. Ratings for previously used medicines highlighted preference for purple, pink, and blue, while white and colourless received moderate scores. A statistically significant link between taste and colour emerged (ρ = 0.42, p- value 2.2 × 10 −16 ), suggesting that the colour of a medicine may influence children’s anticipation of its taste and shape their overall expectations of the treatment experience. Conclusion This study offers valuable insight into children’s preferences for medicine colour. Pink and blue were associated with sweet/flavourful tastes, while neutral colours were perceived as tasteless, particularly by participants aged 12–18 years. These findings can inform paediatric formulation strategies, particularly the selection and use of colouring agents, in alignment with current regulatory requirements when their inclusion is considered necessary.

ORCID iDs

Alessandrini, Elisa, Gizurarson, Sveinbjorn, Walsh, Jennifer, Turner, Roy, Schaufelberger, Daniel, Iurian, Sonia, Batchelor, Hannah ORCID logoORCID: https://orcid.org/0000-0002-8729-9951, Klein, Sandra, Nafria, Begonya, Dicks, Pamela, Gaillard, Segolene, Franz, Axel R., Albano, Jasmin, Wisniewski, Aleksander, Vermehren, Charlotte, Gade, Christina, Andersen, Jon Traerup and Tuleu, Catherine;
CORE (COnnecting REpositories)