In vitro investigation of the PneumoWave biosensor for the identification of central sleep apnea in pediatrics

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Kolukisa Birgec, Burcu and Langley, Ross and Miller, Jennifer and Meredith, Osian and Toprak, Beyza and Mullen, Alexander Balfour (2026) In vitro investigation of the PneumoWave biosensor for the identification of central sleep apnea in pediatrics. Biosensors, 16 (2). 77. ISSN 2079-6374 (https://doi.org/10.3390/bios16020077)

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Abstract

The interpretation and diagnosis of central sleep apnea in pediatrics by nocturnal polysomnography is challenging due to its technical complexity, which involves the simultaneous recording of multiple physiological parameters related to sleep and wakefulness. Furthermore, the unfamiliar environment of a sleep laboratory can hinder sleep evaluation, and diagnostic backlogs are common due to restricted capacity at specialist tertiary centers. The ability to undertake home sleep studies in a familiar environment using simple, robust, and low-cost technology is attractive. The potential to repurpose the PneumoWave biosensor, a UKCA Class 1 device, registered as an accelerometer-based monitoring device that is intended to capture and store chest motion data continuously over a period of time for retrospective analysis, was explored in an in vitro model of central sleep apnea. The PneumoWave system contains a biosensor (PW010), which was able to record simulated apnea episodes of 5 to 20 s across physiologically relevant pediatric breathing rates using an in vitro manikin model and manual annotation. The findings confirm that the PneumoWave biosensor could be a useful technology to support home sleep apnea testing and warrant further exploration.

ORCID iDs

Kolukisa Birgec, Burcu, Langley, Ross, Miller, Jennifer, Meredith, Osian, Toprak, Beyza and Mullen, Alexander Balfour ORCID logoORCID: https://orcid.org/0000-0001-7475-5543;
CORE (COnnecting REpositories)