Leishmaniasis vaccine research : current status and new directions

Topuz Ata, Derya and Ata, Anil and Carter, Chris (Katharine C.) (2026) Leishmaniasis vaccine research : current status and new directions. Parasitology. pp. 1-12. ISSN 0031-1820 (https://doi.org/10.1017/S0031182025101522)

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Abstract

Leishmaniasis is a neglected parasitic disease responsible for significant morbidity and mortality. Currently, there is no vaccine approved for clinical use. Therefore controlling infections in infected individuals depends on interventions to prevent infected female sand flies from biting humans, treatment of clinical infections or alternative treatment methods. This review focuses on the types of vaccine developed to control leishmaniasis and which vaccines have made it through to clinical trials. It also discusses the role CRISPR technology may play in improving vaccine candidates design.