The concise guide to PHARMACOLOGY 2025/26 : Ion channels

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Alexander, Stephen P. H. and Striessnig, Jörg and Gibb, Alasdair J. and Mathie, Alistair A. and Veale, Emma L. and Kelly, Eamonn and Peach, Chloe J. and Armstrong, Jane F. and Faccenda, Elena and Harding, Simon D. and Southan, Christopher and Davies, Jamie A. and Aldrich, Richard W. and Attali, Bernard and Baggetta, Austin M. and Becirovic, Elvir and Beech, David J. and Biel, Martin and Bill, Roslyn M. and Caceres, Ana I. and Catterall, William A. and Chua, Han Chow and Conner, Alex C. and Danahay, Henry and Davies, Paul and De Clerq, Katrien and Delling, Markus and Di Virgilio, Francesco and Falzoni, Simonetta and Fang, Wei and Fenske, Stefanie and Fortuny‐Gomez, Anna and Fountain, Samuel and Chandy, George K. and Ghovanloo, Mohammad‐Reza and Goldstein, Steve A. N. and Gosling, Martin and Grimm, Christian and Grissmer, Stephan and Ha, Kotdaji and Hales, Tim G. and Hammelmann, Verena and Hanukoglu, Israel and Hu, Meiqin and Ijzerman, Ad P. and Jabba, Sairam V. and Jarvis, Mike and Jensen, Anders A. and Jordt, Sven E. and Kaczmarek, Leonard K. and Kellenberger, Stephan and Kennedy, Charles and King, Brian and Kitchen, Philip and Liu, Qiang and Lynch, Joseph W. and Manville, Rian W. and Meades, Jessica and Mehlfeld, Verena and Nicke, Annette and Offermanns, Stefan and Pérez‐Reyes, Edward and Plant, Leigh D. and Pless, Stephan A. and Rash, Lachlan D. and Ren, Dejian and Rubaiy, Hussein N. and Salman, Mootaz M. and Sieghart, Werner and Sivilotti, Lucia G. and Smart, Trevor G. and Snutch, Terrance P. and Tammaro, Paolo and Tian, Jinbin and Trimmer, James S. and Van den Eynde, Charlotte and Vergani, Paola and Vriens, Joris and Waxman, Stephen G. and Wei, Aguan D. and Winn, Brenda T. and Wulff, Heike and Xu, Haoxing and Yang, Fan and Yue, Lixia and Zhang, Xiaoli and Zhu, Michael (2025) The concise guide to PHARMACOLOGY 2025/26 : Ion channels. British Journal of Pharmacology, 182 (S1). S152-S241. ISSN 1476-5381 (https://doi.org/10.1111/bph.70231)

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Abstract

The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear, accessible, and well‐structured, rather than the scope of the content, which spans approximately 500 pages. The Concise Guide summarises the key pharmacological properties of around 1900 human drug targets, and nearly 7000 interactions, involving around 4400 ligands. While the content is a substantially condensed version of the more detailed information and links available at the www.guidetopharmacology.org website, the printed guide serves as a permanent, citable, point‐in‐time record, that remains stable despite ongoing updates to the online database. The full contents of this publication can be found at https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70231. The Concise Guides provide expert‐curated recommendations of ‘Gold Standard’ selective pharmacological tools, available either commercially or as donations, which enable the identification of individual drug targets or families of drug targets. While the Concise Guide offers a more streamlined overview, more comprehensive information, including detailed pharmacological profiles and links to multiple online databases, is available through the Guide to Pharmacology website. The 2025/26 edition of the Concise Guide is based on material current as of mid‐2025, and supersedes all previous editions, including the 2023/24 Guide, and earlier Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), and as such provides official IUPHAR classification and nomenclature for human drug targets, where applicable. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. Each section includes nomenclature guidance, concise summaries, information of the best available pharmacological tools, key references, and suggestions for further reading.

ORCID iDs

Alexander, Stephen P. H., Striessnig, Jörg, Gibb, Alasdair J., Mathie, Alistair A., Veale, Emma L., Kelly, Eamonn, Peach, Chloe J., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Southan, Christopher, Davies, Jamie A., Aldrich, Richard W., Attali, Bernard, Baggetta, Austin M., Becirovic, Elvir, Beech, David J., Biel, Martin, Bill, Roslyn M., Caceres, Ana I., Catterall, William A., Chua, Han Chow, Conner, Alex C., Danahay, Henry, Davies, Paul, De Clerq, Katrien, Delling, Markus, Di Virgilio, Francesco, Falzoni, Simonetta, Fang, Wei, Fenske, Stefanie, Fortuny‐Gomez, Anna, Fountain, Samuel, Chandy, George K., Ghovanloo, Mohammad‐Reza, Goldstein, Steve A. N., Gosling, Martin, Grimm, Christian, Grissmer, Stephan, Ha, Kotdaji, Hales, Tim G., Hammelmann, Verena, Hanukoglu, Israel, Hu, Meiqin, Ijzerman, Ad P., Jabba, Sairam V., Jarvis, Mike, Jensen, Anders A., Jordt, Sven E., Kaczmarek, Leonard K., Kellenberger, Stephan, Kennedy, Charles ORCID logoORCID: https://orcid.org/0000-0001-9661-5437, King, Brian, Kitchen, Philip, Liu, Qiang, Lynch, Joseph W., Manville, Rian W., Meades, Jessica, Mehlfeld, Verena, Nicke, Annette, Offermanns, Stefan, Pérez‐Reyes, Edward, Plant, Leigh D., Pless, Stephan A., Rash, Lachlan D., Ren, Dejian, Rubaiy, Hussein N., Salman, Mootaz M., Sieghart, Werner, Sivilotti, Lucia G., Smart, Trevor G., Snutch, Terrance P., Tammaro, Paolo, Tian, Jinbin, Trimmer, James S., Van den Eynde, Charlotte, Vergani, Paola, Vriens, Joris, Waxman, Stephen G., Wei, Aguan D., Winn, Brenda T., Wulff, Heike, Xu, Haoxing, Yang, Fan, Yue, Lixia, Zhang, Xiaoli and Zhu, Michael;
CORE (COnnecting REpositories)